Search results for "Rheumatic fever"
showing 8 items of 8 documents
The History of Rheumatic Diseases
1975
The lectures of Schonlein* (1873) (Fig. 1) state: The nature of this disease being more dynamic, explains the fact that few abnormalities of significance have been found at autopsy. This statement stems from the inadequacy of the then current methods but also suggests a concept of rheumatic diseases, some ingredients of which have survived to this day. However, even a short review of medical history shows progressive differentiation of various disease entities: originally Hippocrates (460–377 BC) took “Rheuma” and “Catarrh” to be synonymous with a process during which “mucous flux” left the brain for various foci in the entrails and also the joints, and there produced disease. He mentions “…
Leishmaniasis, autoimmune rheumatic disease, and anti–tumor necrosis factor therapy, Europe.
2009
We report 2 cases of leishmaniasis in patients with autoimmune rheumatic diseases in Greece. To assess trends in leishmaniasis reporting in this patient population, we searched the literature for similar reports from Europe. Reports increased during 2004–2008, especially for patients treated with anti–tumor necrosis factor agents.
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity
2012
Membrane microvesicle shedding is an active process and occurs in viable cells with no signs of apoptosis or necrosis. We report here that microvesicles shed by oligodendroglioma cells contain an ‘aggrecanase’ activity, cleaving aggrecan at sites previously identified as targets for adamalysin metalloproteinases with disintegrin and thrombospondin domains (ADAMTSs). Degradation was inhibited by EDTA, the metalloproteinase inhibitor GM6001 and by tissue inhibitor of metalloproteinases (TIMP)-3, but not by TIMP-1 or TIMP-2. This inhibitor profile indicates that the shed microvesicles contain aggrecanolytic ADAMTS(s) or related TIMP-3-sensitive metalloproteinase(s). The oligodendroglioma cells…
Juvenile Rheumatoid Arthritis and Still’s Disease
1975
In the Anglo-American literature, the term “Still’s disease”, based on the observations of ○Cornil (1864) and Still (1897) is generally employed to cover the juvenile forms of rheumatoid arthritis, defined by Ansell and Bywaters (1959). German paediatricians, on the other hand, particularly Storber and Kolle, regard Still’s disease as a separate syndrome. Kolle uses the following characteristics for this distinction: 1. High fever at the commencement of illness. 2. Enlargement of lymph nodes, spleen and liver. 3. Myocarditis and pericarditis. 4. High leucocyte count. 5. Erythema multiforme in about 70% of patients.
Non-Articular Rheumatism
1975
In terms of numbers of the population involved, this type of rheumatism is of the greatest significance.
New diagnostic criteria of acute rheumatic fever: prevalence of silent carditis in a pediatric population
2017
Acute rheumatic fever and its sequel, chronic rheumatic heart disease, are important global health issues with an annual incidence of about 500.000 new cases and a prevalence of 34 million people worldwide affected by rheumatic heart disease. During the 20th century the incidence of ARF and the prevalence declined substantially in Europe, North America, and developed nations in other geographic locations. In Italy the incidence is about 4,1:100.000. Acute rheumatic fever is a systemic inflammatory response to group A streptococcal infection, which typically affects children and occurs two or three weeks after a throat infection. Although arthritis is the most common sign, carditis which com…
Acute rheumatic fever prophylaxis in high-income countries: clinical observations from an Italian multicentre, retrospective study.
2019
Objective-The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of Rheumatic Heart Disease (RHD) in a cohort of Italian patients with Acute Rheumatic Fever (ARF). Methods-This is a multicentre retrospective study. Patients were divided into two groups according to the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated. Results-wo hundred and ninety patients were enrolled (137 females, 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients showed RHD. Adherence to secondary prophylaxis was low in 26% of …
Paediatric acute rheumatic fever in developed countries: Neglected or negligible disease? Results from an observational study in Lombardy (Italy)
2018
Introduction: Acute Rheumatic Fever (ARF) is a multisystemic disease that results from an autoimmune reaction due to group A streptococcal infection. The disease affects predominantly children aged 5 to 15 years and although its incidence in developed Countries declined since the early 1900s, to date there is a paucity of data that confirm this epidemiological trend. Objective: The study aimed to assess the burden of ARF in term of hospitalization and to describe the characteristics of acute rheumatic fever (ARF) in the paediatric population of Lombardy. Study design: The study was carried out by analyzing hospital discharge records of patients resident of Lombardy and aged 0–17 years old w…